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Coleus forskohlii

Coleus forskohlii also known as Plectranthus barbatus, is a well known herb in ancient systems of medicine. According to Ayurveda, Coleus prevents heart disease, convulsion, spasmodic pain and painful urination. Coleus forskohlii roots contain Forskolin, responsible for most of the pharmacological activities of this herb.

Chemically Forskolin belong to the class of diterpenoids, precisely labdane diterpenes. Studies and research on cell physiology has confirmed Forskolin to raise the levels of cyclic AMP (cAMP), a secondary messenger important in many biological processes. cAMP is used for intracellular signal transduction, like transferring the effects of hormones like glucagon and adrenaline into cells as these hormones cannot pass through the cell membrane.

Coleus antiobesity activity has been implicated to be due to elevation of cAMP. Other mechanisms could be appetite suppression.

 

 


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